Michael E Bozik Selected Research

Dexpramipexole

1/2019	Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size.
1/2018	Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes.
1/2017	The targeted eosinophil-lowering effects of dexpramipexole in clinical studies.
9/2014	A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS.
11/2013	Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial.
11/2011	The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis.
8/2011	Safety, tolerability, and pharmacokinetics of KNS-760704 (dexpramipexole) in healthy adult subjects.
1/2008	KNS-760704 [(6R)-4,5,6,7-tetrahydro-N6-propyl-2, 6-benzothiazole-diamine dihydrochloride monohydrate] for the treatment of amyotrophic lateral sclerosis.

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Michael E Bozik Research Topics

Disease

8	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019 - 01/2008
2	Disease Progression 01/2018 - 09/2014
2	Hypereosinophilic Syndrome (Loeffler Endocarditis) 01/2018 - 01/2017
1	Rhinosinusitis 01/2019
1	Eosinophilia 01/2019
1	Nasal Polyps (Nasal Polyp) 01/2019
1	Polyps 01/2019
1	Respiratory Insufficiency (Respiratory Failure) 01/2018
1	Infections 01/2017
1	Neutropenia 11/2013
1	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2011

Drug/Important Bio-Agent (IBA)

8	DexpramipexoleIBA 01/2019 - 01/2008
1	Investigational DrugsIBA 01/2019
1	SteroidsIBA 01/2018
1	Indicators and Reagents (Reagents)IBA 01/2018
1	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2017
1	CreatinineIBA 09/2014
1	Biomarkers (Surrogate Marker)IBA 09/2014
1	DiaminesIBA 08/2011
1	benzothiazoleIBA 08/2011

Therapy/Procedure

2	Therapeutics 01/2019 - 01/2017
1	Tracheostomy 01/2018